In summer 1999 an association was founded under the title Forum for New Media, to support artistic/experimental operating with New Media.
This happened within the scope of the initiative by the Culture Department of the Kantons Basel-Stadt and the Christoph Merian foundation, to get the Viper festival from Luzern to Basel. Apart from that, Basel already had a group of active artists who supported these initiatives.
In winter 1999/2000 a direction post for the Forum for New Media was advertised, including the commission to develop a plan for this new institution. In summer 2000, Annette Schindler became director and in October, she introduced to the public a conception for an online and offline mediation programme and cooperations in production.
The [plug.in] premises at St.Alban-Rheinweg 64 were inaugurated on October 16th and are open to the public until today. With its events and exhibitions [plug.in] soon closed a gap in the cultural life in Basel: A platform was built for the young, vitally developing media art which provided a new form of dealing with art. The [plug.in] activities supported and enforced the manifold media art scene of Basel and there were cooperations with:
Viper; Hyperwerk; Hochschule für Gestaltung und Kunst Basel; Medienwissenschaftliches Seminar der Universität Basel; Point-de-vue; Via; tweaklab; xcult and many other groups and individuals.
In the early summer of 2002 [plug.in] carried out an evaluation by an external expert, Annette Schönholzer. This evaluation showed plainly that [plug.in] is generally appreciated by the public and artists. The number of events, the quality of the programme and the public relation was considered as good or very good as well as the function of [plug.in] as a meeting place for people interested in media art, the interior design and technical infra structure, services in informing and dealing with visitors, [plug.in]'s local and national charisma, the professionality, experimentality and networking.
The artists presented at [plug.in] all considered their cooperation with [plug.in] very good and they appreciated the various advantages resulting from these cooperations.
The interviewed experts rate [plug.in] as a unique institution in Basel and in Switzerland in general which can give a fresh impetus in the growing field of media art. Thanks to its expertly competence, [plug.in] is the most important institution and source of information for those interested in and producing media art in Switzerland.

In 2006, [plug.in] initiated the Shift electronic arts festival. It co-organised it since 2007. Since 2009, [plug.in] helped to establish the House of Electronic Arts Basel on the Dreispitz site. The new institution was formally founded in 2010 as an endowment. In January 2011 it took up operation as a successor institution.

[plug.in] since 2000 with:
Any Affair, Mark America, Inke Arns, Maja Bajevic, Ursula Biemann, !Mediengruppe Bitnik, Blast Theory, Nathalie Bookchin, Nicolas Boulard, Andres Bosshard, Beat Brogle, Shu Lea Cheang, collectif_fact, Nic Collins, Florian Cramer, etoy, exonemo, F18,  Johannes Gees, Graw Böckler, Beverley Hood, JODI, Birgit Kempker, Knowbotic Research, Thomas Köner, Marc Lee, Jürg Lehni, Golan Levin, Lana Lin, Kristin Lucas, Muda Mathis/Sus Zwick, Marlene McCarty, Micromusic, Norbert Möslang, Christian Philipp Müller, n3krozoft mord, Sadie Plant, Marco Poloni, Max Philipp Schmid, Corinna Schnitt, Cornelia Sollfrank, Bruno Spoerri, Bruno Stanek, Monica Studer/Christoph van den Berg, Jan Torpus, Mark Tribe, Zhang Peili, Rolf Pfeifer, Hinrich Sachs, Andrea Saemann, Jill Scott, Barbara Strebel, Felix Stalder, Reinhard Storz, UBERMORGEN.COM, Olaf Val, Jan Verbeek, Yvonne Volkart, Christoph Wachter/Mathias Jud and many more

Cooperations with: dorkbot.swiss, esba Genf, Eyebeam New York, FHNW HGK, F+F Zürich, Fondation Beyeler Riehen, Fri-Art Fribourg, Hartware MedienKunstVerein Dortmund, IfM Uni Basel, Internationale Kurzfilmtage Oberhausen, Jeonju International Film Festival Korea, Museum für Gegenwartskunst Basel, NAMOC Peking, Neue Kunst Halle St.Gallen, point de vue, Tweaklab, Viper, Xcult, ZHdK SNM, and many more